Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version)

PRACTICE GUIDELINES

Hideyuki Ishida1), Tatsuro Yamaguchi2), Kohji Tanakaya3), Kiwamu Akagi4), Yasuhiro Inoue5), Kensuke Kumamoto6), Hideki Shimodaira7), Shigeki Sekine8), Toshiaki Tanaka9), Akiko Chino10), Naohiro Tomita11), Takeshi Nakajima12), Hirotoshi Hasegawa13), Takao Hinoi14), Akira Hirasawa15), Yasuyuki Miyakura16), Yoshie Murakami17), Kei Muro18), Yoichi Ajioka19), Yojiro Hashiguchi20), Yoshinori Ito21), Yutaka Saito22), Tetsuya Hamaguchi23), Megumi Ishiguro24), Soichiro Ishihara9), Yukihide Kanemitsu25), Hiroshi Kawano26), Yusuke Kinugasa27), Norihiro Kokudo28), Keiko Murofushi29), Takako Nakajima30), Shiro Oka31), Yoshiharu Sakai32), Akihiko Tsuji33), Keisuke Uehara34), Hideki Ueno35), Kentaro Yamazaki36), Masahiro Yoshida37), Takayuki Yoshino38), Narikazu Boku23), Takahiro Fujimori39), Michio Itabashi40), Nobuo Koinuma41), Takayuki Morita42), Genichi Nishimura43), Yuh Sakata44), Yasuhiro Shimada45), Keiichi Takahashi2), Shinji Tanaka46), Osamu Tsuruta47), Toshiharu Yamaguchi48), Kenichi Sugihara49), Toshiaki Watanabe9), Japanese Society for Cancer of the Colon and Rectum

1) Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitma Medical University, Kawagoe, Japan
2) Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
3) Department of Surgery, Iwakuni Clinical Center, Iwakuni, Japan
4) Department of Cancer Prevention and Molecular Genetics, Saitama Prefectural Cancer Center, Saitama, Japan
5) Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan
6) Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan
7) Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
8) Division of Pathology and Clinical Laboratories, National Cancer Center, Hospital, Tokyo, Japan
9) Department of Surgical Oncology, The Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
10) Division of Gastroenterology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
11) Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
12) Endoscopy Division/Department of Genetic Medicine and Service, National Cancer Center Hospital, Tokyo, Japan
13) Department of Surgery, Keio University School of Medicine, Tokyo, Japan
14) Department of Surgery, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan
15) Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
16) Department of Surgery Saitama Medical Center, Jichi Medical University, Saitama, Japan
17) Department of Oncology Nursing, Faculty of Nursing, Toho University, Tokyo, Japan
18) Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
19) Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
20) Department of Surgery, Teikyo University, Tokyo, Japan
21) Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan
22) Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
23) Division of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
24) Department of Translational Oncology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
25) Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan
26) Department of Gastroenterology, St. Mary's Hospital, Fukuoka, Japan
27) Department of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan
28) Hepato‐Pancreato‐Biliary Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
29) Radiation Oncology Department, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
30) Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki, Japan
31) Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan
32) Department of Surgery, Kyoto University, Kyoto, Japan
33) Department of Clinical Oncology, Faculty of Medicine, Kagawa University, Takamatsu, Japan
34) Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
35) Department of Surgery, National Defense Medical College, Saitama, Japan
36) Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan
37) Department of Hemodialysis and Surgery, Chemotherapy Research Institute, International University of Health and Welfare, Ichikawa, Japan
38) Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan
39) Diagnostic Pathology Center, Shinko Hospital, Kobe, Japan
40) Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan
41) Department of Health Administration and Policy, Tohoku Medical and Pharmaceutical University, Sendai, Japan
42) Department of Surgery, Cancer Center, Aomori Prefectural Central Hospital, Aomori, Japan
43) Department of Surgery, Japanese Red Cross Kanazawa Hospital, Ishikawa, Japan
44) CEO, Misawa City Hospital, Misawa, Japan
45) Division of Clinical Oncology, Kochi Health Sciences Center, Kochi, Japan
46) Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
47) Division of GI Endoscopy, Kurume University School of Medicine, Fukuoka, Japan
48) Department of Gastroenterological Surgery, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
49) Koujinkai Daiichi Hospital, Tokyo, Japan

Abstract:

Hereditary colorectal cancer accounts for less than 5% of all colorectal cancer cases. Some of the unique characteristics that are commonly encountered in cases of hereditary colorectal cancer include early age at onset, synchronous/metachronous occurrence of the cancer, and association with multiple cancers in other organs, necessitating different management from sporadic colorectal cancer. While the diagnosis of familial adenomatous polyposis might be easy because usually 100 or more adenomas that develop in the colonic mucosa are in this condition, Lynch syndrome, which is the most commonly associated disease with hereditary colorectal cancer, is often missed in daily medical practice because of its relatively poorly defined clinical characteristics. In addition, the disease concept and diagnostic criteria for Lynch syndrome, which was once called hereditary non‐polyposis colorectal cancer, have changed over time with continual research, thereby possibly creating confusion in clinical practice. Under these circumstances, the JSCCR Guideline Committee has developed the "JSCCR Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (HCRC)," to allow delivery of appropriate medical care in daily practice to patients with familial adenomatous polyposis, Lynch syndrome, or other related diseases. The JSCCR Guidelines 2016 for HCRC were prepared by consensus reached among members of the JSCCR Guideline Committee, based on a careful review of the evidence retrieved from literature searches, and considering the medical health insurance system and actual clinical practice settings in Japan. Herein, we present the English version of the JSCCR Guidelines 2016 for HCRC.

Released: January 19, 2018; doi: dx.doi.org/10.23922/jarc.2017-028
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