Oral rehydration solution normalizes plasma renin and aldosterone levels in patients with ulcerative colitis after proctocolectomy


Katsuyoshi Kudoh1), Chikashi Shibata2), Yuji Funayama3), Kouhei Fukushima4), Kenichi Takahashi5), Munenori Nagao1), Sho Haneda5), Kazuhiro Watanabe1), Takeshi Naitoh1), Michiaki Unno1)

1) Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
2) Tohoku Medical and Parmaceutical University, Sendai, Japan
3) Sendai Sekijuji Hospital, Sendai, Japan
4) Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan
5) Tohoku Rosai Hospital, Sendai, Japan


Objectives: The possible effects and benefits of oral rehydration solution (ORS) on chronic dehydration after total proctocolectomy. Methods: To evaluate the effect of ORS on the renin-angiotensin system after remnant proctocolectomy in patients with ulcerative colitis (UC), we selected 20 patients after remnant proctocolectomy, ileal J pouch-anal anastomosis, and construction of a diverting ileostomy for UC. Patients were randomly divided into two groups, A (n=9) or B (n=11), 2 weeks after the surgery. In group A, ORS (1000 mL/day) was given for the first 7 days and mineral water (1000 mL/day) for the next 7 days. In group B, mineral water (1000 mL/day) was given for the first 7 days and ORS (1000 mL/day) for next 7 days. Plasma levels of renin, aldosterone and excretion of sodium in urine were evaluated at days 0, 7, and 14. We defined day 0 as the day of beginning this study. Results: Mean plasma renin levels on day 0 were six to eight times greater than the upper normal limit. In group A, ORS lowered plasma renin levels. In group B, plasma levels of renin and aldosterone after ORS were lower than those at days 0 and 7. Conclusions: ORS corrected increased plasma levels of renin and aldosterone to within the normal range in patients after proctocolectomy.

Released: July 28, 2017; doi: dx.doi.org/10.23922/jarc.2016-015